Indications and Usage
Phentermine® (phentermine hydrochloride) is indicated as ashortterm (a few weeks) adjunct in a regimen of weight reduction based onexercise, behavioral modification and caloric restriction in the management ofexogenous obesity for patients with an initial body mass index >=30 kg/m2,or >=27 kg/m2 in the presence of other risk factors (e.g., hypertension,diabetes, hyperlipidemia). Below is a chart of Body Mass Index (BMI) based on variousheights and weights. BMI is calculated by taking the patient's weight, inkilograms (kg), divided by the patient's height, in meters (m), squared. Metricconversions are as follows: pounds ÷ 2.2 = kg; inches x 0.0254 = meters.
Height (feet, inches)
phentermine (Phentermine) chart of body mass index (BMI)
Warnings
Phentermine® is indicated only as short-termmonotherapy for the management of exogenous obesity. The safety and efficacy ofcombination therapy with phentermine and any other drug products for weightloss, including selective serotonin reuptake inhibitors (e.g., fluoxetine,sertraline, fluvoxamine, paroxetine), have not been established. Therefore,coadministration of these drug products for weight loss is not recommended. Primary Pulmonary Hypertension (PPH) - a rare,frequently fatal disease of the lungs - has been reported to occur in patientsreceiving a combination of phentermine with fenfluramine or dexfenfluramine.The possibility of an association between PPH and the use of phentermine alonecannot be ruled out; there have been rare cases of PPH in patients whoreportedly have taken phentermine alone. Theinitial symptom of PPH is usually dyspnea. Other initial symptoms include:angina pectoris, syncope or lower extremity edema. Patients should be advisedto report immediately any deterioration in exercise tolerance. Treatment shouldbe discontinued in patients who develop new, unexplained symptoms of dyspnea,angina pectoris, syncope or lower extremity edema. Valvular Heart Disease: Serious regurgitant cardiacvalvular disease, primarily affecting the mitral, aortic and/or tricuspidvalves, has been reported in otherwise healthy persons who had taken acombination of phentermine with fenfluramine or dexfenfluramine for weightloss. The etiology of these valvulopathies has not been established and theircourse in individuals after the drugs are stopped is not known. The possibilityof an association between valvular heart disease and the use of phenterminealone cannot be ruled out; there have been rare cases of valvular heart diseasein patients who reportedly have taken phentermine alone. Tolerance to the anorectic effect usually develops within afew weeks. When this occurs, the recommended dose should not be exceeded in anattempt to increase the effect; rather, the drug should be discontinued. Phentermine® may impair the ability of the patient to engagein potentially hazardous activities such as operating machinery or driving amotor vehicle; the patient should therefore be cautioned accordingly. Order phentermine online
Overdosage
Manifestations of acute overdosage with phentermine includerestlessness, tremor, hyperreflexia, rapid respiration, confusion,assaultiveness, hallucinations, panic states. Fatigue and depression usuallyfollow the central stimulation. Cardiovascular effects include arrhythmia,hypertension or hypotension, and circulatory collapse. Gastrointestinalsymptoms include nausea, vomiting, diarrhea and abdominal cramps. Fatalpoisoning usually terminates in convulsions and coma. Management of acute phentermine intoxication is largelysymptomatic and includes lavage and sedation with a barbiturate. Experiencewith hemodialysis or peritoneal dialysis is inadequate to permitrecommendations in this regard. Acidification of the urine increasesphentermine excretion. Intravenous phentolamine (Regitine®, CIBA) has beensuggested for possible acute, severe hypertension, if this complicatesphentermine overdosage. Order phentermine online
Adverse Reactions
Cardiovascular:Primary pulmonary hypertension and/or regurgitant cardiac valvular disease (seeWarnings), palpitation, tachycardia, elevation of blood pressure. Central Nervous System: Overstimulation, restlessness, dizziness, insomnia, euphoria,dysphoria, tremor, headache; rarely psychotic episodes at recommended doses. Gastrointestinal:Dryness of the mouth, unpleasant taste, diarrhea, constipation, othergastrointestinal disturbances. Allergic: Urticaria.Endocrine: Impotence, changes in libido. Order phentermine online
How Supplied
Available in tablets and capsules containing 37.5 mgphentermine hydrochloride (equivalent to 30 mg phentermine base). Each blue andwhite, oblong, scored tablet is debossed with "Phentermine" and"9"-"9". The #3 capsule has an opaque white body and anopaque bright blue cap. Each capsule is imprinted with "Phentermine" -"37.5" on the cap and two stripes on the body using dark blue ink. Tablets are packaged in bottles of 30 (NDC 57844-009-56);100 (NDC 57844-009-01); and 1000 (NDC 57844-009-10). Capsules are packaged in bottles of 100 (NDC 57844-019-01).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Dispense in a tight container as defined in the USP, with achildresistant closure (as required). Order phentermine online
